Polyketide synthases

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Originated in SF 1866936

Examples of multistep polyketide biosynthetic processes. To do: check that none of these happen in a concerted process (very unlikely).

Contents

[edit] Three malonyl transfers and three decarboxylations

  • benzophenone synthase activity (GO:0047181), EC:2.3.1.151
  • acridone synthase activity (GO:0050635), EC:2.3.1.159

[edit] Three malonyl transfers and four decarboxylations

  • naringenin-chalcone synthase activity (GO:0016210), EC:2.3.1.74
  • 6'-deoxychalcone synthase activity (GO:0033808), EC:2.3.1.170
  • pinosylvin synthase activity (GO:0050198), EC:2.3.1.146
  • trihydroxystilbene synthase activity (GO:0050350), EC:2.3.1.95
  • phloroisovalerophenone synthase activity (GO:0050634), EC:2.3.1.156
  • 6-methylsalicylic acid sytnhase activity (GO:0050641), EC:2.3.1.165

These are actually multistep processes involving three malonyl transfers and four decarboxylations. The overall details are described in PMID: 11959984. The reaction specifics for GO:0016210 are in PMID: 10653632, which describes how it's a succession of malonyl-CoA decarboxylations followed by transfer of the acetyl group to the polyketide chain.

[edit] Six malonyl transfers

  • erythronolide synthase activity (GO:0047879), EC:2.3.1.94

[edit] Eight malonyl transfers

  • lovastatin nonaketide synthase activity (GO:0050637), EC:2.3.1.161

the clue here is in the synonym: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing)

[edit] Uncounted

  • mycocerosate synthase activity (GO:0050111), EC:2.3.1.111
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